Call NOVA Health Recovery at 703-844-0184 for IV Vitamin, NAD+, and Ketamine infusions for depression.
Vitamin B6 for depression and inflammation
Vitamin B6 is an essential vitamin that the body cannot make. It is water-soluble and is obtained only through the diet. It exists in 6 different forms, but two forms are most important:
- Pyridoxal 5’-Phosphate (PLP)
- Pyridoxamine 5’-phosphate (PMP)
PLP and PMP act as coenzymes, meaning that they participate in making an enzyme work better in its reactions. PLP functions as part of over 100 reactions including the formation of neurotransmitters such as dopamine and serotonin, as well as DNA and RNA. It is also involved in immune functions and regulates homocysteine levels, which has cardiovascular effects – high levels of homocysteine can be linked to coronary artery disease.
PLP is a coenzyme for aromatic L-amino acid decarboxylase (AADC) which converts L-DOPA and 5-HTP into dopamine and serotonin.
PLP is also a cofactor for 5-aminolevulinic acid synthase, which produces heme for your red blood cells. This is the oxygen carrying molecule. PLP is involved in inflammation as it acts as a cofactor for the kynurenine pathway, a pathway that regulates inflammation and recruitment of immune cells.
Vitamin B6, as PLP, is involved in the regulation of homocysteine, an amino acid produced in the body during the methionine cycle. Homocysteine is usually converted to cysteine through the transulfuration pathway, which vitamin B6 plays a role in. High levels of homocysteine are thought to damage arteries and promote clots that result in heart attacks and stroke.
So the key points for Vitamin B6:
- The RDA for Vitamin B6 is 1.3-1.7 mg/day
- The Linus Pauling Institute recommends more than 2 mg a day if you are age 50 or older
- Vitamin B6 is found in chickpeas (1.1 mg/cup serving), Beef Liver (0.9 mg/3 oz serving), Tuna (0.9 mg/ 3 oz serving) , chicken breast (0.5 mg/3 oz serving)
- Plant-based foods contain less absorbable Vitamin B6 (pyridoxine Glucoside)
- An optimal PLP level is above 30 nmol/L
- PLP is involved in the production of neurotransmitters (dopamine/serotonin), hemoglobin, DNA, RNA, and immune function.
Low levels of Vitamin B6 are associated with:
Certain genetic traits increase the risk of low Vitamin B6:
- APLPL genes encode alkaline phosphatase that is involved in degrading PLP. SNP within the ALPL gene, rs1256335, creates two different variants or ‘alleles’: the ‘G’ allele and the ‘A’ allele. Those with the G allele have lower PLP levels. A ‘C’ allele of the ALPL gene, created by the rs4654748 SNP is also associated with lower Vitamin B6 levels as the C allele may be more efficient in clearing the Vitamin B6
- NBPF3 (neuroblastoma breakpoint family, member 3) gene is located close to the ALPL gene. The role of this gene in Vitamin B6 metabolism is not known but can produce lower PLP levels.
Other things that reduce Vitamin B6 include:
- Inflammatory Bowel Disease
The bottom line: Watch your vitamin support as vitamins play key roles in metabolism at multiple levels of metabolism. If you are suffering from depression or inflammatory conditions, consider getting IV Vitamin support to help boost your neurotransmitters and anti-inflammatory effects.
At NOVA Health Recovery, we offer multiple recipes of vitamin mixtures to support your health and recovery. If you are depressed and undergoing ketamine infusions, consider doing vitamin infusions as well to support dopamine and serotonin production. If you have an addiction, vitamin B will be low as well. Vitamin B6 helps produce dopamine, which is low during addiction.
Call us at 703-844-0184 NOVA Health Recovery