Shortening of telomeres results in the side effects of aging – the breakdown of tissues. So reversing telomere shortening or preventing it, should, in theory , be life-prolonging and healthful. Below is a Longevity Mix of Nutraceuticals that each have evidence for telomerase activation:
Fortified foods, beverages, supplements and creams aim to help people look and feel better as they age.
Silymarin: 200 Mg 2x a day N- Acetyl Cysteine : 1800 -2400 mg/day Resveratrol: 10-20 mg daily Green Tea (EGCG): 50 mg a day Ginkgo Biloba: 40-80 mg cycled every 4 weeks Acetyl L- Carnitine 1000 mg aday Vitamin C 540 mg a day minimum L-Arginine : 500 mg-1000 mg a day Alpha tocopherol: 400 IU a day Vitamin D3 : 2000 IU daily Folic Acid : 2-5 mg daily
Milk Thistle for helping out with telomeres: American Indians used this as a health inducing tonic:
Silymarin boosts Telomerase activity by 300% and reduces the number of senescent cells. It also increases the number of endothelial progenitor cells by 64%:
Silymarin Inhibits Endothelial Progenitor Cells’ Senescence and Protects Against the Antiproliferative Activity of Rapamycin: Preliminary Study
Journal of Cardiovascular Pharmacology. 56(6):610-618, DEC 2010 DOI: 10.1097/FJC.0b013e3181f78dc
N- Acetyl Cysteine
A building block for the master anti-oxidant, Glutathione. It delays decay of endothelial cells by hTERT activation.
Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients Mech Ageing Dev. 2008 May; 129(5): 261–270.
One of the four lesser known forms of Vitamin E may modulate the length of telomeres by telomerase and exposure to it for just 24 hours seemed to lengthen telomeres by 16%.This has been seen in multiple studies.
Increases telomerase activity and prevents endothelial cells from dying.
Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms
Br J Pharmacol. 2008 Oct; 155(3): 387–394.
Resveratrol also suppresses cellular proliferation and induces DNA repair, and facilitates HDL production
ECGC Has a powerful effect on telomeres, lengthening them by .46 Kilobases longer in green tea drinkers – the equivalent of 5 years of life lengthening.
- Chinese tea consumption is associated with longer telomere length in elderly Chinese men
Ginkgo Biloba activates Telomerase in endothelial cells of blood vessels
Ginkgo Biloba Extract Reduces Endothelial Progenitor-Cell Senescence Through Augmentation of Telomerase Activity Journal of Cardiovascular Pharmacology. 49(2):111-115, FEB 2007
Acetyl L carnitine combined with choline can affect the symptoms of Alzheimers and causes nerge growth factor to be produced.
also increases telomerase activity as well and slows down the shortening of telomeres by 64%
L- Arginine and alpha tocopherol also turn on Telomerase as well.
Cycloastraganol is a telomerase activator of TAT2 from the Astragalus root. Click on the link above:
Article Below from Bullet Proof: