Mood IV Drips

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IV Choices :

Good Mood IV
We’ve figured out how to put you in a good mood intravenously.

You want to feel calm and happy with life; content but also focused, right? For that you’ll need the help of your neurotransmitters. What are neurotransmitters? They are molecules that constantly convey messages between our nerve cells. This IV was designed to help you attain optimal neurotransmitter function. It provides important B vitamins which play key roles in the formation and breakdown of neurotransmitters such as serotonin and dopamine as well as vitamin C which helps produce norepinephrine. To help maintain a calm focus, GPC is added to the mix. And magnesium and taurine will help you stay mellow and relaxed. While doing this treatment, it is important to orally restore yourself as well: Liposomal Vitamin C

Science

This is important because Ach is a key player in your autonomic nervous system the part that governs unconscious activities like heart rate, breathing, bowel, kidney and bladder function and even muscle contraction. In the brain Ach pathways also control arousal, plasticity of the brain, reward, sensory perception, and sustained attention. This neurotransmitter has also been shown to promote REM sleep (2). Damage to the cholinergic (acetylcholine-producing) system in the brain has been shown to be associated with the memory deficits seen in Alzheimer’s disease (1). Maintaining healthy levels of Ach is thus very beneficial for the overall healthy functioning of the entire body especially the brain and getting enough GPC helps you do just that.

Other neurotransmitters involved in reward, cravings, pleasure, energy and attention are serotonin, dopamine and norepinephrine. Vitamin C is important in the conversion of dopamine to norepinephrine. The manufacture and breakdown of these neurotransmitters also depends on methylation and energy production. Most of the B-vitamins but especially B2, B6 and B12 play a crucial role in both the production of energy in the TCA cycle and in the methylation cycle.

Taurine is classified by many as an amino acid, although, it is technically not one of the 22 amino acid building blocks of protein. It has a very broad role in the body. For example it helps with bile acid conjugation, membrane stabilization, inhibitory neurotransmission (think anti-anxiety) and neuro-protection. In one study taurine was shown to decrease the impulse to drink alcohol. (3) It also plays a role as an antioxidant, blood pressure regulator and in the regulation of dangerous cholesterol particles involved in atherosclerosis.

Magnesium is a mineral with a wide variety of functions. It participates in over 300 metabolic reactions. It is a key element in the production of neurotransmitters such as serotonin. It also causes immediate muscle relaxation. When you experience anything that’s tight or stiff—including your mood—it’s likely low levels of magnesium are a contributing factor.

References

Francis PT, Palmer AM, Snape M, Wilcock GK. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. Journal of Neurology, Neurosurgery & Psychiatry, 66(2), 137-147.
Platt B, Riedel G. The cholinergic system, EEG and sleep. Behavioural brain research, 221(2), 499-504.
Olive, MF. Interactions between taurine and ethanol in the central nervous system. Amino acids,23(4), 345-357.
This purpose of this review will be to summarize the interactions between the endogenous amino acid taurine and ethyl alcohol (ethanol) in the central nervous system (CNS). Taurine is one of the most abundant amino acids in the CNS and plays an integral role in physiological processes such as osmoregulation, neuroprotection and neuromodulation. Both taurine and ethanol exert positive allosteric modulatory effects on neuronal ligand-gated chloride channels (i.e., GABA_A and glycine receptors) as well as inhibitory effects on other ligand- and voltage-gated cation channels (i.e., NMDA and Ca²⁺ channels). Behavioral evidence suggests that taurine can alter the locomotor stimulatory, sedating, and motivational effects of ethanol in a strongly dose-dependent manner. Microdialysis studies have revealed that ethanol elevates extracellular levels of taurine in numerous brain regions, although the functional consequences of this phenomenon are currently unknown. Finally, taurine and several related molecules including the homotaurine derivative acamprosate (calcium acetylhomotaurinate) can reduce ethanol self-administration and relapse to drinking in both animals and humans. Taken together, these data suggest that the endogenous taurine system may be an important modulator of effects of ethanol on the nervous system, and may represent a novel therapeutic avenue for the development of medications to treat alcohol abuse and alcoholism.
Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neuroscience & Biobehavioral Reviews. ClinicaltrialsofNacetylcysteineinpsychiatryandneurologyAsystemaicreview (1)

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B2 (riboflavin)

B2 (riboflavin): Vitamin B2 is especially critical in energy production, methylation, and DNA and RNA synthesis. Symptoms of deficiency include headaches, fatigue, and irritability.

B12 (cobalamin)

B12 (cobalamin): B12 is found mainly in animal foods and cannot be manufactured in the human body. Absorption is very complex and requires stomach acid, intrinsic factor, pancreatic enzymes and intact stomach and small intestine cells.This vitamin is a key player in the Krebs cycle and in the methylation cycle as it is a critical cofactor in homocysteine conversion to methionine by the enzyme methionine synthase. In its absence the processing of methylfolate and other steps in folate metabolism stop. This blockage of proper folate (B9) metabolism results in anemia and deficiencies in DNA formation.

Other symptoms of B12 deficiency are demyelination (as in multiple sclerosis), slowed nerve conduction, accumulation of homocysteine and increased heart disease risk, defective cell membranes (branched fatty acids), anemia, fatigue, painful and burning feet, skin abnormalities, retarded growth, dizzy spells, digestive disturbances, vomiting, restlessness, stomach stress, and muscle cramps.

Taurine

Taurine: Taurine is an organic acid found abundantly throughout our bodies. It promotes cardiovascular health, insulin sensitivity, electrolyte balance, hearing, bile acid production, healthy cholesterol levels, neuro-modulation, and immune modulation.Taurine works on the same receptors in the brain as glycine and GABA to cause relaxation. It may also have a neuro-protective role against glutamate toxicity and it definitely has a role as an antioxidant.

B5 (pantothenic acid)

B5 (pantothenic acid): B5 is used in the synthesis of coenzyme A and CoA and is a component of the acyl carrier protein (ACP) domain of fatty acid synthase. It’s not important that you know what these particular chemicals do. What you need to understand is that vitamin B5 is required for the metabolism of all carbohydrates, fats and proteins, and it plays a critical indirect role in at least 70 enzymatic reactions in your body.Deficiencies of B5 can lead to symptoms such as painful and burning feet, skin abnormalities, retarded growth, dizzy spells, digestive disturbances, vomiting, restlessness, stomach stress, and muscle cramps.

Magnesium (Mg)

Magnesium (Mg): Magnesium is a mineral and a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. Magnesium is required for energy production, oxidative phosphorylation, and glucose utilization. It is also required for the synthesis of DNA, RNA and the antioxidant glutathione among other functions.

Vitamin C (ascorbate)

Vitamin C (ascorbate): Vitamin C cannot be made in the human body and has to be ingested in food or taken via supplementation. It is a powerful antioxidant, and is required in the production of several critical enzymes as well as the synthesis of collagen from proline and lysine. That means this humble vitamin is required for the maintenance of normal connective tissue (ligaments, tendons, skin), wound healing, and bone remodeling.Vitamin C is also required for conversion of tyrosine to epinephrine (adrenaline). That’s why it is present in high amounts in the adrenal gland cortex and these levels are depleted after adrenocorticotropic hormone (ACTH) stimulation of the gland and synthesis of the stress hormone cortisol. That means under times of high stress (whether from illness, psychological stress, or some other form) your vitamin C levels are liable to plummet.

B6 (pyroxidine)

B6 (pyroxidine): Vitamin B6 plays a unique role in the synthesis of neurotransmitters like serotonin, dopamine, norepinephrine, epinephrine, and GABA. It is also important in amino acid synthesis and it plays a critical role in the methylation cycle.Deficiency is caused by poor diet, alcoholism, and malabsorption or poor digestion. Symptoms of deficiency include headaches, muscle weakness, anemia, nervousness, anxiety, insomnia, skin eruptions, mental fatigue, “brain fog” or mental sluggishness, and hair loss.

Glycerophosphocholine (GPC)

Glycerophosphocholine (GPC also known at Apha-GPC) is a very well studied naturally occurring compound which is part of every cell as well as mother’s milk. It is a precursor to acetylcholine (Ach) and it crosses the “blood brain barrier”—in other words it can work in the brain itself to increase levels of acetylcholine almost immediately.In a 2012 study of healthy human volunteers (1) plasma levels of choline were significantly elevated 60 and 120 minutes after oral intake. This study also showed that GPC naturally increased growth hormone (GH) production and fat breakdown (fatty oxidation) at 60 minutes post ingestion as an added benefit. Another study by Ceda et al corroborated this finding about the relationship between GPC and GH showing that GH levels improved with the use of GPC in the elderly (2).

GH regulates many processes in the body. It improves lean body mass index and helps tissues recover more quickly and effectively from stress, for example.

Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M.. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. Nutrition, 28(11), 1122-1126.

Ceda GP, Marzani GP, Tontodonati V, Piovani E, Banchini A, Baffoni MT, Hoffman AR. Effects of an acetylcholine precursor on GH secretion in elderly subjects. In Growth Hormone II (pp. 328-337). Springer New York.

Glutamine

L-glutamine: Glutamine is an important amino acid that may help maintain muscle, boost the immune system, support gastrointestinal health, and sustain healthy growth hormone levels.
Of the 20 amino acids needed for protein synthesis, glutamine is the most abundant. Under normal circumstances, the body synthesizes enough glutamine to carry out regular functions. However, factors as varied as viral infections, surgery, burns, infectious disease, and even prolonged exercise can significantly deplete levels of this multifunctional amino acid. That’s important, because L-glutamine has a wide variety of actions in the body.For example, clinical studies have found that glutamine supplements strengthen the immune system and reduce infections especially after strenuous or prolonged workouts.

It’s also good for your gut. Intestinal cells are heavy users of glutamine for energy production. This amino acid is also essential for maintaining the structural integrity of the intestinal lining. Insufficient glutamine may lead to a loss of gut mucosal integrity, which can allow toxins and infectious agents to be absorbed into the blood stream. This condition, known as increased intestinal permeability or “leaky gut” may be associated with health problems such as allergies, skin disorders, and Crohn’s disease. In addition, the villi in your small intestine which are responsible for nutrient absorption from food regenerate with the use of glutamine.

Finally, we know that L-glutamine has an impact on the release of growth hormone (GH) which is secreted by the pituitary and is a critical hormone in tissue repair, maintenance of lean body mass, muscle and bone growth. In two different studies researchers have shown that oral supplementation of 2-10 grams of glutamine boosted growth hormone production by as much as 70%.

Inositol

Inositol is also known as Vitamin B9. It is vitals for health and plays a key role in: nerve transmission, cell messaging, prevention of fatty liver, prevention of fatty deposits in the heart, hair growth, breakdown of fats. Inositol supplementation may aid in anxiety, depression, panic disorder, insulin signaling, fat and energy metabolism.

Glycine

L-Glycine is an amino acid biosynthesised in the liver from the amino acids, serine and threonine. As a solid, it’s a sweet tasting crystalline substance and the principle amino acid within cane sugar. In humans, it’s found in high concentrations within the skin, connective tissues and muscle tissues. Glycine helps with the breakdown of fat by regulating the concentration of bile acids. Glycine is also required for the biosynthesis of heme. Heme is a key component of haemoglobin. Haemoglobin is essential in the maintenance of red blood cell integrity and optimal oxygen carrying capacity. Within the central nervous system glycine works together with taurine and gamma-amino butyric acid (GABA) as an inhibitory neurotransmitter (similar to the action of the drug valium). Glycine interferes with the hyper-excitability of the central nervous system. There have been numerous studies investigating the benefits of this amino acid in the treatment of disorders such as hyperactivity, schizophrenia, bipolar, and epilepsy. BLOOD SUGAR: Glycine also assists with the regulation of blood sugars by converting glucose into energy. MUSCLE STRENGTH: Glycine is one of the amino acids necessary for the biosynthesis of creatine. Creatine provides muscles with a direct energy source and helps to build muscle tissue and strength. ANTI-AGING: Glycine is an important anti-aging amino acid. COLLAGEN: Approximately one third of collagen is comprised of glycine. Collagen is the essential protein required to keep the connective tissue and skin flexible and firm. HORMONES: This amino acid can be methylated into dimethylglycine (DMG). DMG plays an important role in the one-carbon pathway that’s essential for the biosynthesis of steroids such as estrogenic and androgenic hormones. Glycine also helps to stimulate the secretion of human growth hormone.

Tryptophan

Tryptophan is one of the essential amino acids our bodies use to make protein and it can’t be synthesized so it has to be obtained from the food we eat. Tryptophan is the main ingredients in the synthesis of the neurotransmitters Serotonin and Melatonin which regulate mood, contentment and sleep. Low serotonin levels lead to irritability and supplementation with tryptophan has been shown to improve mood, anxiety, aggression, addictive behavior, memory, sleep, eating behavior, temperature control, pain and endocrine regulation.

Niacinamide

Niacinamide (nicotinamide) or vitamin B3 is a precursor for co-factors NAD+/ NADH and NADP/ NADPH. NAD+ and NADP+ act as antioxidants that are important in a variety of cellular pathways that affect skin physiology, energy formation in the mitochondria, Sirtuins production (anti-aging), and neurotransmitter function (serotonin). Niacinamide also has broad anti-inflammatory activity. It inhibits nuclear factor kappa B (Nf-kB), and reduces production of a variety of inflammatory cytokines like IL-1 and IL-12. Both oral and topical forms of Niacinamide have been used to treat inflammatory skin conditions. Niacinamide and Niacin are both well known in their role as natural anxiety relievers.

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Purpose for this mixture:

Relaxing
Periods of High Stress
Periods of Poor Ssleep
Anxiety
Mood Restoration
Focus

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