How many Ketamine infusions per week should you have to treat depression?

NOVA Health Recovery Ketamine Infusion Center in Fairfax, Virginia

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A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression 

Singh JB, Fedgchin M, Daly EJ, De Boer P, Cooper K, Lim P, Pinter C, Murrough JW, Sanacora G, Shelton RC, Kurian B, Winokur A, Fava M, Manji H, Drevets WC, Van Nueten L. A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression. Am J Psychiatry. 2016 Aug 1;173(8):816-26. doi: 10.1176/appi.ajp.2016.16010037. Epub 2016 Apr 8. PMID: 27056608. 

When you have finally taken the step of deciding to get ketamine infusions, what would be the best dosing frequency you should receive from your ketamine treatment provider? A study by Dr. JB Singh evaluated this question. 

Treatment resistant depression (TRD) is defined as the failure of two or more medications for an adequate period.  Up to 35% of patients fail to respond to medication therapies. 

Many studies have demonstrated the rapid antidepressant effect of ketamine infusions within 2-24 hours.  (a,b,c,d

How long does a single ketamine infusion last in the treatment of depression? The average range is 3-17 days. 

Ketamine infusions done three times a week over two weeks last 11-27 days in terms of loss of response. For some patients, the depression stays in remission while others have a slow return of depression. 

Six infusions over 12 days demonstrated 25% response after the first dose and 91% response after 6 doses and the effect lasted 7 – 27 days on average. Weekly initial infusions are unlikely to allow for response. 

Most studies have demonstrated progressive improvement of depression with each infusion. 

One Study infused TRD patients three times a week for two weeks and reported response rates of 62.5% after the first infusion and 70.8% by the 6th infusion

Another study using a similar profile demonstrated a 25% response at the first infusion and 92% response to TRD by the 6th infusion. 

This study addressed the efficacy of multiple infusions on the outcomes of depression with either two infusions per week or three infusions per week. The dosing was 0.5 mg/kg IV over 40 minutes. The results demonstrated: 68.8% response at day 15 for twice-weekly infusions and 53.8% response at Day 15 for three times a week infusion series.  

Side effects of the infusions: transient psychomimetic and dissociative symptoms and nausea. This resolved within two hours. 

Change in Montgomery-Åsberg Depression Rating Scale (MADRS) Score, by Dose Frequency, From Baseline Through Day 15 of the Double-Blind Phase in a Study of Intravenous Ketamine in Treatment-Resistant Depression 

The bottom line: It doesn’t matter if the ketamine dosing is twice a week for the initial ketamine infusion or three times a week as the results are similar for TRD. 

NOVA Health Recovery is a Ketamine Treatment Center in Fairfax, Virginia (Northern Virginia Ketamine) that specializes in the treatment of depression, anxiety, bipolar disorder, OCD, and chronic pain such as CRPS, cluster headaches, and fibromyalgia using Ketamine therapies, both infusion and home-based ketamine nasal spray and oral tablets. We also offer addiction treatment services with Suboxone, Vivitrol, and Sublocade therapies for opiate addiction as well as alcohol treatment regimens. Contact us at 703-844-0184 or at this link: NOVA Health Recovery Ketamine Infusion Center N

Ketamine Infusion Center Near me | Alexandria Virginia Ketamine | Ketamine Provider | Ketamine near me | Psychedelic assisted therapy | Mushrooms | Ketamine assisted psychotherapy | Ketamine psychedelic therapy | KAP | K hole | New depression Treatments | Areas we serve:

Maryland (MD):

Bethesda 20814 – Bethesda 20816 – Bethesda 20817 – Chevy Chase 20815 – Colesville 20904 – Cabin John 20815 – Glen Echo 20812 – Gaithersburg 20855 – Gaithersburg 20877- Gaithersburg 20878 – Gaithersburg 20879 – Garrett Park 20896 – Kensington 20895 – Montgomery Village 20886 – Olney 20830 – Olney 20832 – Potomac 20854 – Potomac 20859 – Rockville 20850 – Rockville 20852 – Rockville 20853 – Silver Spring 20903 – Silver Spring 20905 – Silver Spring 20906 – Silver Spring 20910 – Takoma Park 20912 – Wheaton 20902

Washington DC:

Crestwood 20011- North Capitol Hill 20002 – Cathedral Heights 20016 – American University Park 20016 – Columbia Heights 20010 – Mount Pleasant 20010 – Downtown 20036 – Dupont Circle 20009 – Logan Circle 20005- Adams Morgan 20009 – Chevy Chase 20015 – Georgetown 20007 – Cleveland Park 20008 – Foggy Bottom 20037 – Rock Creek Park – Woodley Park 20008 – Tenleytown 20016

Northern Virginia:

McLean 22101- McLean 22102 – McLean 22106 – Great Falls 22066 – Arlington 22201 – Arlington 22202 – Arlington 22203 – Arlington 22205 – Falls Church 22041 – Vienna 22181 – Alexandria 22314 – 22308 -22306 -22305 -22304  Fairfax – 20191 – Reston – 22009 – Springfield – 22152  22015  Lorton 22199

Fairfax, Va

2303 –  22307 – 22306 – 22309 – 22308 22311 – 22310 – 22312

22315 -22003 – 20120 – 22015 – 22027 20121 – 22031 –  20124

22030 – 22033 – 22032 – 22035 – 22039 22041 – 22043

22042 – 22046 – 22044 – 22060 – 22066 20151 – 22079 – 20153 – 22101

22102 – 20171 – 20170 – 22124 – 22151 22150 – 22153

22152 – 20191 – 20190 – 22181- 20192 22180 – 20194 –  22182

Woodbridge – 22191 – 22192 -22193 -22194 – 22195 

Springfield – 22150 – 22151 -22152-22153-22154-22155 -22156 – 22157 -22158 -22159 -22160 – 22161 

Front Royal 22630

Warren County 22610 22630 22642 22649

Fredericksburg Va 22401 22402 – 22403 – 22404 -22405 -22406 -22407 -22408 – 22412 

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20105 Aldie Loudoun County 20106 Amissville Culpeper County 20107 Arcola Loudoun County

20108 Manassas Manassas City 20109 Sudley Springs Prince William County

20109 Manassas Prince William County 20110 Manassas Manassas City

20111 Manassas Prince William County 20111 Manassas Park Prince William County

20112 Manassas Prince William County 20113 Manassas Park Manassas Park City

20115 Marshall Fauquier County 20116 Marshall Fauquier County

20117 Middleburg Loudoun County 20118 Middleburg Loudoun County

20119 Catlett Fauquier County – 20120 Sully Station Fairfax County

20120 Centreville Fairfax County – 20121 Centreville Fairfax County

20122 Centreville Fairfax County – 20124 Clifton Fairfax County

20128 Orlean Fauquier County -20129 Paeonian Springs Loudoun County

20130 Paris Clarke County

20131 Philomont Loudoun County 20132 Purcellville Loudoun County

20134 Hillsboro Loudoun County 20134 Purcellville Loudoun County

20135 Bluemont Clarke County 20136 Bristow Prince William County

20137 Broad Run Fauquier County 20138 Calverton Fauquier County

20139 Casanova Fauquier County 20140 Rectortown Fauquier County

20141 Round Hill Loudoun County 20142 Round Hill Loudoun County

20143 Catharpin Prince William County

20144 Delaplane Fauquier County20146 Ashburn Loudoun County

20147 Ashburn Loudoun County 20148 Brambleton Loudoun County

20148 Ashburn Loudoun County 20151 Chantilly Fairfax County

20151 Fairfax Fairfax County 20152 South Riding Loudoun County

20152 Chantilly Loudoun County 20152 Fairfax Loudoun County

20153 Chantilly Fairfax County 20153 Fairfax Fairfax County

20155 Gainesville Prince William County 20156 Gainesville Prince William County

20158 Hamilton Loudoun County 20159 Hamilton Loudoun County

20160 Lincoln Loudoun County 20160 Purcellville Loudoun County

20163 Sterling Loudoun County 20164 Sterling Loudoun County

20165 Potomac Falls Loudoun County 20165 Sterling Loudoun County

20166 Dulles Loudoun County 20166 Sterling Loudoun County

20167 Sterling Loudoun County 20168 Haymarket Prince William County

20169 Haymarket Prince William County 20170 Herndon Fairfax County

20171 Oak Hill Fairfax County 20171 Herndon Fairfax County

20172 Herndon Fairfax County 20175 Leesburg Loudoun County

20176 Lansdowne Loudoun County 20176 Leesburg Loudoun County

20177 Leesburg Loudoun County 20178 Leesburg Loudoun County

20180 Lovettsville Loudoun County 20181 Nokesville Prince William County

20182 Nokesville Prince William County 20184 Upperville Fauquier County

20185 Upperville Fauquier County 20186 Warrenton Fauquier County

20187 New Baltimore Fauquier County 20187 Vint Hill Farms Fauquier County 20187 Warrenton Fauquier County

20188 Vint Hill Farms Fauquier County 20188 Warrenton Fauquier County

20190 Reston Fairfax County 20190 Herndon Fairfax County

20191 Reston Fairfax County 20191 Herndon Fairfax County

20194 Reston Fairfax County 20194 Herndon Fairfax County

20195 Reston Fairfax County 20195 Herndon Fairfax County

20197 Waterford Loudoun County 20198 The Plains Fauquier County

Loudon County:

Loudoun County, VA – Standard ZIP Codes

20105 | 20117 | 20120 | 20129 | 20130 | 20132 | 20135 | 20141 | 20147 | 20148 | 20152 | 20158 | 20164 | 20165 | 20166 | 20175 | 20176 | 20180 | 20184 | 20189 | 20197 | 22066

Ashburn, VA – Standard ZIP Codes
20147 20148
Leesburg, VA – Standard ZIP Codes
20175 20176
Sterling, VA – Standard ZIP Codes
20164 20165 20166

Waterford, VA 20197

Dulles, VA – Standard ZIP Codes
20166 20189
Purcellville, VA – Standard ZIP Codes
20132
Chantilly, VA – Standard ZIP Codes
20151 20152

Mcclean, Va Zip codes: 220432204622066,221012210222207

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