Skin and Collagen Amino Acid support | 703-844-0184 | Alexandria, Va 22306 | IV drip | IV doctors

Skin and Collagen IV Amino Acid Therapies

Amino acids are the building blocks of life. Our body uses 23 amino acids, connected in different patterns to build protein molecules. Why is this important? Because your whole body is made of protein. It is used in the synthesis of muscle (actin, myosin), skin and connective tissues (collagen), enzymes (digestion of food) and hormones (insulin, growth hormone, thyroid hormone).

Amino acids are even used to make neurotransmitters like serotonin, dopamine, adrenaline and GABA, which influence our moods, carvings and behaviors.

It goes without saying that we need a constant supply of amino acids to maintain optimal health. The problem is many people don’t get enough amino acids despite eating abundant amounts.

When this happens your body doesn’t have the raw materials required to synthesize compounds that build your body and keep you healthy. This IV is designed to begin to solve that problem. It is the fastest and most effective way to deliver amino acids directly into your circulation, boosting your reserves and sending them to your cells in high concentration.

We recommend advanced testing to see which amino acids may need replacement, although testing is not necessary to begin therapy. Repeated infusions of higher amounts of amino acids and customized amino acid therapy may be needed to relieve chronic deficiency.

What’s in the mixture?

L-Glycine is an amino acid biosynthesised in the liver from the amino acids, serine and threonine. As a solid, it’s a sweet tasting crystalline substance and the principle amino acid within cane sugar. In humans, it’s found in high concentrations within the skin, connective tissues and muscle tissues. Glycine helps with the breakdown of fat by regulating the concentration of bile acids. Glycine is also required for the biosynthesis of heme. Heme is a key component of haemoglobin. Haemoglobin is essential in the maintenance of red blood cell integrity and optimal oxygen carrying capacity. Within the central nervous system glycine works together with taurine and gamma-amino butyric acid (GABA) as an inhibitory neurotransmitter (similar to the action of the drug valium). Glycine interferes with the hyper-excitability of the central nervous system. There have been numerous studies investigating the benefits of this amino acid in the treatment of disorders such as hyperactivity, schizophrenia, bipolar, and epilepsy. BLOOD SUGAR: Glycine also assists with the regulation of blood sugars by converting glucose into energy. MUSCLE STRENGTH: Glycine is one of the amino acids necessary for the biosynthesis of creatine. Creatine provides muscles with a direct energy source and helps to build muscle tissue and strength. ANTI-AGING: Glycine is an important anti-aging amino acid. COLLAGEN: Approximately one third of collagen is comprised of glycine. Collagen is the essential protein required to keep the connective tissue and skin flexible and firm. HORMONES: This amino acid can be methylated into dimethylglycine (DMG). DMG plays an important role in the one-carbon pathway that’s essential for the biosynthesis of steroids such as estrogenic and androgenic hormones. Glycine also helps to stimulate the secretion of human growth hormone.

Manganese (Mn): Manganese is a mineral involved in collagen building and fat metabolism. It promotes a healthy nervous system, and is necessary for digestive function, bone growth, and immune function. In addition, manganese is necessary for the proper function of mitochondrial superoxide dismutase (SOD2) which catalyzes the same reaction as that catalyzed by the cytosolic version, SOD1.

B12 (cobalamin): B12 is found mainly in animal foods and cannot be manufactured in the human body. Absorption is very complex and requires stomach acid, intrinsic factor, pancreatic enzymes and intact stomach and small intestine cells.This vitamin is a key player in the Krebs cycle and in the methylation cycle as it is a critical cofactor in homocysteine conversion to methionine by the enzyme methionine synthase. In its absence the processing of methylfolate and other steps in folate metabolism stop. This blockage of proper folate (B9) metabolism results in anemia and deficiencies in DNA formation.
Other symptoms of B12 deficiency are demyelination (as in multiple sclerosis), slowed nerve conduction, accumulation of homocysteine and increased heart disease risk, defective cell membranes (branched fatty acids), anemia, fatigue, painful and burning feet, skin abnormalities, retarded growth, dizzy spells, digestive disturbances, vomiting, restlessness, stomach stress, and muscle cramps.

L-proline: One of 20 amino acids which are the building blocks of protein. It is not an essential amino acid, which means that the human body can synthesize it. Proline is biosynthetically derived from the amino acid l-glutamate. Multiple prolines and/or hydroxyprolines in a row can create a helix, the predominant secondary structure in collagen. The hydroxylation of proline by prolyl hydroxylase increases the stability of collagen significantly.=

B2 (riboflavin): Vitamin B2 is especially critical in energy production, methylation, and DNA and RNA synthesis. Symptoms of deficiency include headaches, fatigue, and irritability.

Vitamin C (ascorbate): Vitamin C cannot be made in the human body and has to be ingested in food or taken via supplementation. It is a powerful antioxidant, and is required in the production of several critical enzymes as well as the synthesis of collagen from proline and lysine. That means this humble vitamin is required for the maintenance of normal connective tissue (ligaments, tendons, skin), wound healing, and bone remodeling. Vitamin C is also required for conversion of tyrosine to epinephrine (adrenaline). That’s why it is present in high amounts in the adrenal gland cortex and these levels are depleted after adrenocorticotropic hormone (ACTH) stimulation of the gland and synthesis of the stress hormone cortisol. That means under times of high stress (whether from illness, psychological stress, or some other form) your vitamin C levels are liable to plummet.

L-lysine: One of 20 amino acids which are the building blocks of protein. Lysine is an essential amino acid, meaning that it has to be obtained from food and cannot be manufactured by the human body.Some studies have found that lysine may be beneficial for those with herpes simplex infections, however, it has not been approved by the FDA for herpes simplex suppression.
Lysine has an anxiolytic (reduces anxiety) action through its effects on serotonin receptors in the intestinal tract, and is also hypothesized to reduce anxiety through serotonin regulation in the amygdala.This amino acid plays a major role in calcium absorption, building muscle protein, recovering from surgery or sports injuries, and the body’s production of hormones, enzymes, and antibodies. Lysine is also necessary in the production of collagen. Collagen contains hydroxylysine, which is derived from lysine by lysyl hydroxylase.

B6 (pyroxidine): Vitamin B6 plays a unique role in the synthesis of neurotransmitters like serotonin, dopamine, norepinephrine, epinephrine, and GABA. It is also important in amino acid synthesis and it plays a critical role in the methylation cycle. Deficiency is caused by poor diet, alcoholism, and malabsorption or poor digestion. Symptoms of deficiency include headaches, muscle weakness, anemia, nervousness, anxiety, insomnia, skin eruptions, mental fatigue, “brain fog” or mental sluggishness, and hair loss.

Glutathione (GSH): Glutathione is the “master” antioxidant. It neutralizes free radicals such as superoxide and reactive oxygen species (ROS) like hydroxy radicals, peroxynitrites, and hydroperoxides, all of which are byproducts of oxygen metabolism in the mitochondria. Free radicals and ROS can cause damage to DNA, proteins and cell membranes altering their function, causing mutations and may be implicated in chronic illnesses like cancer or heart disease. Glutathione renders these molecules inert, protecting you from their destructive effects.
Detoxification is another major function of glutathione. GSH attaches to substances like heavy metals and xenobiotics—molecules that need to be excreted—forming “conjugates” that make them easier to be eliminated by the liver via bile and the kidneys via urine.

B2 (riboflavin): Vitamin B2 is especially critical in energy production, methylation, and DNA and RNA synthesis. Symptoms of deficiency include headaches, fatigue, and irritability.

Vitamin H, more commonly known as biotin, is part of the B complex group of vitamins. All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy.Biotin deficiency is associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. Biotin is also used orally for hair loss, brittle nails, skin rash diabetes, mild depression and in high doses to treat Multiple Sclerosis.

Niacinamide (nicotinamide) or vitamin B3 is a precursor for co-factors NAD+/ NADH and NADP/ NADPH. NAD+ and NADP+ act as antioxidants that are important in a variety of cellular pathways that affect skin physiology, energy formation in the mitochondria, Sirtuins production (anti-aging), and neurotransmitter function (serotonin). Niacinamide also has broad anti-inflammatory activity. It inhibits nuclear factor kappa B (Nf-kB), and reduces production of a variety of inflammatory cytokines like IL-1 and IL-12. Both oral and topical forms of Niacinamide have been used to treat inflammatory skin conditions. Niacinamide and Niacin are both well known in their role as natural anxiety relievers.

Science

What Causes Amino Acid Deficiency?

Essential amino acids cannot be made by our bodies. They must come from food. Some of us simply don’t get enough from our diet. But more commonly, the problem is that we cannot properly break down and assimilate the protein we do eat. This is called malabsorption, and it actually affects how well all macronutrients (proteins, carbohydrates and fats) and micronutrients (vitamins, minerals) are processed and taken up by our digestive tract. Malabsorption can occur for a number of reasons.

You may not be able to properly break down food. This is referred to as maldigestion, and it is usually caused by deficiencies in stomach acid, pepsin, or digestive enzymes. Protein digestion begins in the stomach where pepsin is secreted. This triggers the pancreas to release pancreatic enzymes into the small intestine. If this process is inhibited or you don’t produce enough of these chemicals, protein is not properly broken down and you don’t get the amino acids you need.

Another associated problem is intestinal inflammation. This can cause damage to the layer of small intestine cells that play an essential role in digesting protein. These cells contain enzymes that activate the pancreatic enzymes mentioned above. They are also responsible for the uptake of amino acids into the digestive tract, into the lymph vessels that transport nutrients to the liver, and into the circulation. When these intestinal cells  are damaged, these functions cannot be performed correctly.

Common conditions that lead to damage and intestinal inflammation are:

  • Abdominal surgery
  • Pancreatitis
  • Liver damage
  • Alcoholism
  • Opioid Recovery
  • Infections
  • Diabetes
  • Small Bacterial Overgrowth (SIBO)
  • Antibiotics
  • Auto-immune Diseases – e.g. Celiac, Crohn’s Disease, Systemic Lupus
  • Stress
  • Intense Exercise

The good news is that a growing body of research shows that amino acids can heal the intestinal damage from inflammation while providing your body the needed components for protein synthesis.

Amino Acids Heal Intestinal Damage from Inflammation

We have begun to learn more about how amino acids improve intestinal health from what may seem an unlikely population: burn victims. You see, people who suffer from burns have a tremendous stress response after their injuries, and this quickly manifests itself as stomach ulcers and gut inflammation.

Interestingly, a study (1) done if 2015 of 24 patients with recent burn injuries showed that early treatment with an oral solution containing L-glutamine prevented damage to the intestinal barrier, promoted repair and alleviated the inflammatory response.

This is prescient to our discussion here, because L-glutamine is a very abundant amino acid, and is the preferred fuel for the cells of the intestinal tract. It contributes significantly to the repair and regrowth of the cells of the intestinal tract, allowing for better digestion and absorption of all other nutrients and amino acids.

Another amino acid, L-arginine, was studied together with L-glutamine, and this combination has been shown to heal inflammation of the gut and repair what is called “leaky gut”—a leading cause of malabsorption. In a 2015 study2 on animals, investigators showed that treatment with L-arginine and L-glutamine prevented colitis (inflammation) and repaired intestinal epithelial cells preventing abnormal “bacterial translocation” – a condition where bacteria from the gut “leak through” into the circulation causing inflammation in the entire body.

Amino Acids as Triggers for Hormones

Certain amino acids have powerful actions as triggers for hormones. For example L-arginine IV infusions are usually given to diagnose growth hormone deficiency as was done in a recent 2015 study of 243 children.3 The normal response to an L-arginine amino acid IV infusion is an immediate spike in growth hormone production. Those who do not respond can be suspected as having a growth hormone deficiency.

Neurotransmitters and Amino Acids

Another critical function of amino acids is building neurotransmitters— molecules that influence our behavior, mood, cravings and sleep.

One of the most important neurotransmitters is serotonin, which is derived from the amino acid L-tryptophan. Low levels of serotonin can cause insomnia, cravings for sweets, depression, and anxiety. Most of the major prescription antidepressants work by affecting serotonin levels. However, supplementing with L-tryptophan can raise the levels of serotonin naturally and may work much faster.

In one study (4) 59 healthy women aged 45-65 were given a diet rich in L-tryptophan. The results were impressive. The women experienced improved moods, faster reaction times, “high energy”, sustained attention and higher levels of happiness. These volunteers began to ignore “negative thinking” and had more positive outlooks.

But serotonin isn’t the only neurotransmitter impacted by amino acids. Dopamine and norepinephrine—responsible for our levels of contentment and alertness, respectively—are also built from these essential compounds. In a recent review (5) investigators concluded that supplementation with the amino acid L-tyrosine improved levels of dopamine and norepinephrine in the short-term, reduced stress, and lead to improved cognitive performance. In yet another review (6) the authors concluded that supplementation with L-tryosine or another amino acid, phenylalanine, raised dopamine levels in the brain.

References

1 Sun, K., et al. Effects of early oral administration of mixed enteral nutritional agent on intestinal mucosal barrier of patients with severe burn injury]. Zhonghua shao shang za zhi= Zhonghua shaoshang zazhi= Chinese journal of burns. 31.1 (2015): 25-29.

2 Andrade, Maria Emília Rabelo, et al. Pretreatment and Treatment With L-Arginine Attenuate Weight Loss and Bacterial Translocation in Dextran Sulfate Sodium Colitis. Journal of Parenteral and Enteral Nutrition. (2015): 0148607115581374.

3 Al Khalifah, Reem, Lina Moisan, and Helen Bui. The shortened combined clonidine and arginine test for growth hormone deficiency is practical and specific: a diagnostic accuracy study. Journal of Pediatric Endocrinology and Metabolism. (2015).

4 Mohajeri, M. H., et al. Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women. British Journal of Nutrition. 113.02 (2015): 350-365.

5 Jongkees, Bryant J., et al. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of psychiatric research. 70 (2015): 50-57.

6 Fernstrom, John D., and Madelyn H. Fernstrom. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. The Journal of nutrition. 137.6 (2007): 1539S-1547S.

Use this with:

Country Life – Max-Amino with Vitamin B-6 (Blend of 18 Amino Acids) – 180 Vegetarian Capsules 

Great Lakes Gelatin – Collagen Hydrolysate Kosher – Unflavored Protein – 16 oz 

Core Vitamin Therapies

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